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Amping Up Immunity to Respiratory Viruses by Targeting Memory T Cells in the Lungs | Microbiology

While we have realized that an infection with the SARS-CoV-2 virus, which causes COVID-19, may cause issues in many organ systems, the lungs can maintain significant damage in many extreme circumstances. Researchers are attempting to be taught extra about how immune cells in the lungs react to the virus, which may inform the improvement of a vaccine for SARS-CoV-2 and different viruses. Scientists at the Salk Institute have now realized that it is simpler than thought to activate immune cells that reside in the lungs and are concerned in long-term immunity. The findings have been reported in the Journal of Experimental Medicine.

“Inside our lungs exist long-lived killer T cells that recognize specific viruses and protect us against reinfection, should we encounter the virus again. Our results have elucidated the manner by which these cells see the virus upon reinfection and provide rapid immunity,” mentioned the examine chief, Salk Professor Susan Kaech, director of Salk’s NOMIS Center for Immunobiology and Microbial Pathogenesis. “It also may help us understand long-term immunity as it relates to coronavirus.”

If our physique is uncovered to a pathogenic invader like the flu virus, a sort of immune cell known as killer T cells can destroy these invaders, or tackle a memory of them in order that if there’s a second encounter with the pathogen, the T cells can react extra shortly. This is (a simplification of) how our physique establishes long-term immunity, and vaccines reap the benefits of the course of by giving the immune system simply sufficient of publicity so that it’ll have the capability to battle the pathogen if an an infection ever occurs.

While researchers learn about the activation of reminiscence T cells in organs like the lymph nodes, for instance, dendritic cells are recognized to play an essential in T cell activation in half by exposing the T cells to fragments of the pathogen. Less is understood about whether or not or how this occurs in another organs like the lungs.

In this examine, the researchers used a mouse mannequin to take away numerous forms of dendritic cells one by one to see whether or not the reminiscence T cells in the lungs would acknowledge a second an infection.

“At first, our results were disappointing because it didn’t seem like our experiments were working; the killer memory T cells in the lungs continued to recognize the virus after the deletion of many different messenger cell types,” mentioned first examine creator Jun Siong Low, now a postdoctoral fellow at the Institute for Research in Biomedicine (IRB) at the Università della Svizzera Italiana, in Switzerland. “Soon, we realized that these lung-resident killer memory T cells were special because they were not reliant on any single type of messenger cell. Instead, they could see the second influenza infection through a variety of different messenger cells, including non-immune cells like lung epithelial cells, which was a remarkably exciting finding.”

Memory T cells in the lymph nodes want dendritic cells to react to a second publicity to a virus, so the bodily location of reminiscence T cells appears to dictate how they’re reactivated. When they’re contaminated, virtually any form of cell can reactivate reminiscence T cells, suggesting that vaccines that work on the reminiscence T cells in the lungs could also be particularly efficient.

“We will take this knowledge into our next study, where we will examine whether lung-resident killer memory T cells form after a coronavirus infection,” mentioned Kaech. “Since not all infections induce killer memory T cells, we will determine if these cells form after a coronavirus infection and whether they can be protective against future coronavirus infections.”

Sources: AAAS/Eurekalert! by way of Salk Institute, Journal of Experimental Medicine

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